Rapid chylomicron appearance following sequential meals: effects of second meal composition.

Journal article

Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-rich meals. An earlier study has shown that the triacylglycerol in this early peak originates from a previous meal. The present study was performed to investigate the effects of different second meals on the plasma triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested one of the following in a balanced design: a fat-rich meal, a low-fat meal, water or nothing by mouth. Blood samples were taken for 2.5 h following the second meal. An early peak in chylomicron and plasma triacylglycerol concentrations was seen following both low-fat and fat-rich second meals but not following water. During studies investigating postprandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.

Authors: Evans, K; Kuusela, P; Cruz, M; Wilhelmova, I; Fielding, B

• Publication status: Published
• Journal: British journal of nutrition
• Volume: 79
• Issue: 5
• Pages: 425-429
• Publication date: 1998-05-01
• DOI: 10.1079/bjn19980072
• EISSN: 1475-2662
• ISSN: 0007-1145
• Language: English
• Keywords: Eating; Triglycerides; Dietary Fats; Adult; Humans; Drinking; Postprandial Period; Male; Analysis of Variance; Chylomicrons