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Journal article

Increased expression of the diabetes gene SOX4 reduces insulin secretion by impaired fusion pore expansion

Abstract:

The transcription factor Sox4 has been proposed to underlie the increased type-2 diabetes risk linked to an intronic SNP in CDKAL1. In a mouse model expressing a mutant form of Sox4, glucose-induced insulin secretion is reduced by 40% despite normal intracellular Ca(2+) signalling and depolarization-evoked exocytosis. This paradox is explained by a 4-fold increase in kiss-and-run exocytosis (as determined by single-granule exocytosis measurements), in which the fusion pore connecting the gran...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db15-1489

Authors


Publisher:
American Diabetes Association
Journal:
Diabetes More from this journal
Volume:
65
Issue:
7
Pages:
1952-1961
Publication date:
2016-07-01
Acceptance date:
2016-03-08
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Language:
English
Keywords:
Pubs id:
pubs:611550
UUID:
uuid:07652542-5308-4af6-8b6f-e6e79515bc5c
Local pid:
pubs:611550
Source identifiers:
611550
Deposit date:
2016-05-05

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