The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice.

Journal article

A longitudinal study of lymphocytic infiltration in the endocrine pancreas of non-obese diabetic mice was performed to investigate the role of different lymphocyte subsets in the pathogenesis of diabetes. The incidence of insulitis and the percentage of mononuclear cell subsets in the pancreas were evaluated in non-obese diabetic mice of various ages (5, 9, 13, 17, 22, 29 and 36 weeks). Cryostat sections of pancreas were stained with heamatoxilin-eosin or with different monoclonal antibodies ...

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Authors: Signore, A; Pozzilli, P; Gale, E; Andreani, D; Beverley, P

• Journal: Diabetologia
• Volume: 32
• Issue: 5
• Pages: 282-289
• Publication date: 1989-05-01
• DOI: 10.1007/bf00265543
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Antigens, Surface; Islets of Langerhans; Immunoenzyme Techniques; Antibodies, Monoclonal; Lymphocytes; Diabetes Mellitus, Experimental; Animals; Female; Mice, Mutant Strains; Mice