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Cytosolic [Ca2+] regulation of InsP3-evoked puffs.

Abstract:

InsP3-mediated puffs are fundamental building blocks of cellular Ca2+ signalling, and arise through the concerted opening of clustered InsP3Rs (InsP3 receptors) co-ordinated via Ca2+-induced Ca2+ release. Although the Ca2+ dependency of InsP3Rs has been extensively studied at the single channel level, little is known as to how changes in basal cytosolic [Ca2+] would alter the dynamics of InsP3-evoked Ca2+ signals in intact cells. To explore this question, we expressed Ca2+-permeable channels ...

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Publisher copy:
10.1042/bj20121271

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The Biochemical journal
Volume:
449
Issue:
1
Pages:
167-173
Publication date:
2013-01-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:075cf567-7692-4ee8-a859-6826ac895ed0
Source identifiers:
354098
Local pid:
pubs:354098

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