Allele-specific antibodies to Plasmodium falciparum merozoite surface protein-2 and protection against clinical malaria.

Journal article

IgG and IgG3 antibodies to merozoite surface protein-2 (MSP-2) of Plasmodium falciparum have been associated with protection from clinical malaria in independent studies. We determined whether this protection was allele-specific by testing whether children who developed clinical malaria lacked IgG/IgG3 antibodies specific to the dominant msp2 parasite genotypes detected during clinical episodes. We analysed pre-existing IgG and IgG1/IgG3 antibodies to antigens representing the major dimorphic...

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Authors: Osier, F; Murungi, L; Fegan, G; Tuju, J; Tetteh, K

• Publication status: Published
• Journal: Parasite immunology
• Volume: 32
• Issue: 3
• Pages: 193-201
• Publication date: 2010-03-01
• DOI: 10.1111/j.1365-3024.2009.01178.x
• EISSN: 1365-3024
• ISSN: 0141-9838
• Language: English
• Keywords: Animals; DNA, Protozoan; Antibodies, Protozoan; Malaria, Falciparum; Child, Preschool; Infant; Antigens, Protozoan; Protozoan Proteins; Polymerase Chain Reaction; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Plasmodium falciparum; Alleles; Humans