Journal article
Synovial tissue research: a state-of-the-art review
- Abstract:
- The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches. In this Review, we describe these approaches, and summarize how their use in synovial tissue research has improved our understanding of rheumatoid arthritis and identified candidate biomarkers that could be used in disease diagnosis and stratification, as well as in predicting disease course and treatment response.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 332.3KB, Terms of use)
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(Preview, Other, pdf, 59.1KB, Terms of use)
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- Publisher copy:
- 10.1038/nrrheum.2017.115
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Reviews Rheumatology More from this journal
- Volume:
- 13
- Issue:
- 8
- Pages:
- 463-475
- Publication date:
- 2017-07-01
- DOI:
- EISSN:
-
1759-4804
- ISSN:
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1759-4790
- Pubs id:
-
pubs:815402
- UUID:
-
uuid:07519bb4-1702-43e1-ae20-87954808d385
- Local pid:
-
pubs:815402
- Source identifiers:
-
815402
- Deposit date:
-
2018-01-08
- ARK identifier:
Terms of use
- Copyright holder:
- Macmillan Publishers, part of Springer Nature.
- Copyright date:
- 2017
- Rights statement:
- © 2017 Macmillan Publishers, part of Springer Nature. All rights reserved
- Notes:
- This is the accepted manuscript version of the article. The final version is available from Nature at: https://doi.org/10.1038/nrrheum.2017.115. A correction to this article is available at: https://doi.org/10.1038/nrrheum.2017.161
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