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Bacterial superantigen facilitates epithelial presentation of allergen to T helper 2 cells.

Abstract:

Although clinical and laboratory evidence support roles for both staphylococcal infection and environmental allergens in the pathogenesis of atopic dermatitis, human studies have largely considered these variables independently. We sought to test the hypothesis that staphylococcal superantigen influences the allergen-specific T cell response. We first mapped a Der p 1 epitope and used HLA DRB1*1501 class II tetramer-based cell sorted populations to show that specific CD4(+) T cells were able ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0700733104

Authors


Ardern-Jones, MR More by this author
Bateman, EA More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
13
Pages:
5557-5562
Publication date:
2007-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:07470f20-318c-4467-8ad3-8f7da251abd7
Source identifiers:
27711
Local pid:
pubs:27711

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