- Abstract:
-
The loss of HIV-specific CD8+ T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8+ T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8+ T cell functional evolution from primary to chronic HIV infection. We observed a profound expansion of perforin+ CD8+ T cells immediately following HIV infection that quickly waned after acute viremia resolution...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.4MB)
-
- Publisher copy:
- 10.1371/journal.ppat.1005805
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Pathogens Journal website
- Volume:
- 12
- Issue:
- 8
- Pages:
- e1005805
- Publication date:
- 2016-08-05
- Acceptance date:
- 2016-07-11
- DOI:
- EISSN:
-
1553-7374
- ISSN:
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1553-7366
- Pubs id:
-
pubs:638087
- URN:
-
uri:074457a2-6689-4bd5-84a6-dbef18bf85f3
- UUID:
-
uuid:074457a2-6689-4bd5-84a6-dbef18bf85f3
- Local pid:
- pubs:638087
- Language:
- English
- Keywords:
- Copyright holder:
- No Copyright
- Copyright date:
- 2016
- Notes:
- This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Journal article
Temporal dynamics of CD8+ T cell effector responses during primary HIV infection.
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Quebec Health Research Fund
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