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Journal article

Temporal dynamics of CD8+ T cell effector responses during primary HIV infection.

Abstract:

The loss of HIV-specific CD8+ T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8+ T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8+ T cell functional evolution from primary to chronic HIV infection. We observed a profound expansion of perforin+ CD8+ T cells immediately following HIV infection that quickly waned after acute viremia resolution...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Role:
Author
ORCID:
0000-0003-0633-1719

Contributors

Role:
Editor
More from this funder
Name:
Canadian Institutes of Health Research
Grant:
HIG-133050
More from this funder
Name:
National Institutes of Health
Grant:
P30 AI045008
More from this funder
Name:
Quebec Health Research Fund
Publisher:
Public Library of Science
Journal:
PLoS Pathogens More from this journal
Volume:
12
Issue:
8
Pages:
e1005805
Publication date:
2016-08-01
Acceptance date:
2016-07-11
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
27486665
Language:
English
Keywords:
Pubs id:
pubs:638087
UUID:
uuid:074457a2-6689-4bd5-84a6-dbef18bf85f3
Local pid:
pubs:638087
Source identifiers:
638087
Deposit date:
2018-01-29

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