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Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

Abstract:

Genome-wide association studies have identified many genetic variants associated with complex traits. However, at only a minority of loci have the molecular mechanisms mediating these associations been characterized. In parallel, whereas cis regulatory patterns of gene expression have been extensively explored, the identification of trans regulatory effects in humans has attracted less attention. Here we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-act...

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Publication status:
Published

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Publisher copy:
10.1038/ng.833

Authors


Hedman, AK More by this author
Grundberg, E More by this author
Thorleifsson, G More by this author
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Journal:
NATURE GENETICS
Volume:
43
Issue:
6
Pages:
561-U90
Publication date:
2011-06-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:0743af3d-c0d2-4e3f-9cbb-100f097aa772
Source identifiers:
149867
Local pid:
pubs:149867

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