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Proton permeation through the myocardial gap junction.

Abstract:

Although protons can directly or indirectly gate solute permeability of the myocardial gap junction, there is little information regarding their own permeation, despite their importance in the regulation of myocardial contractility and rhythm. By pipette-loading of acid into guinea pig isolated, ventricular myocyte pairs while imaging pH(i) confocally using SNARF fluorescence, we have observed that protons permeate the junctional region. Permeation is inhibited by glycyrrhetinic acid, an agen...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
Circulation research
Volume:
93
Issue:
8
Pages:
726-735
Publication date:
2003-10-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:073f5432-0887-4c09-91fd-918a17c20c02
Source identifiers:
106236
Local pid:
pubs:106236

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