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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

Abstract:

Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study. In a combined meta-analysis, we identified a SNP, rs11212617, associated with treatment success (n = 3,920, P = 2.9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-...

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Publisher copy:
10.1038/ng.735

Authors


Bellenguez, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Bennett, AJ More by this author
Coleman, RL More by this author
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Journal:
Nature genetics
Volume:
43
Issue:
2
Pages:
117-120
Publication date:
2011-02-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:073ef72e-be12-49e2-b179-10d9e567270f
Source identifiers:
118163
Local pid:
pubs:118163

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