- Abstract:
-
Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study. In a combined meta-analysis, we identified a SNP, rs11212617, associated with treatment success (n = 3,920, P = 2.9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-...
Expand abstract - Publisher copy:
- 10.1038/ng.735
-
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- Journal:
- Nature genetics
- Volume:
- 43
- Issue:
- 2
- Pages:
- 117-120
- Publication date:
- 2011-02-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:073ef72e-be12-49e2-b179-10d9e567270f
- Source identifiers:
-
118163
- Local pid:
- pubs:118163
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
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