Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.
Our understanding of the composition of multi-clonal malarial infections and the epidemiological factors which shape their diversity remain poorly understood. Traditionally within-host diversity has been defined in terms of the multiplicity of infection (MOI) derived by PCR-based genotyping. Massively parallel, single molecule sequencing technologies now enable individual read counts to be derived on genome-wide datasets facilitating the development of new statistical approaches to describe w...Expand abstract
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file: :C$$:/Users/dominic/Dropbox/Refs/2012/Auburn et al._2012_Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data(2).pdf:pdf
keywords: Alleles,Animals,Antigens, Protozoan,Antigens, Protozoan: genetics,Biodiversity,Burkina Faso,Genetic Variation,Genome,Genome-Wide Association Study,Genotype,Humans,Mali,Models, Genetic,Models, Statistical,Plasmodium falciparum,Plasmodium falciparum: genetics,Polymerase Chain Reaction,Polymerase Chain Reaction: methods,Polymorphism, Single Nucleotide,Sequence Analysis, DNA
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