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Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.

Abstract:

Our understanding of the composition of multi-clonal malarial infections and the epidemiological factors which shape their diversity remain poorly understood. Traditionally within-host diversity has been defined in terms of the multiplicity of infection (MOI) derived by PCR-based genotyping. Massively parallel, single molecule sequencing technologies now enable individual read counts to be derived on genome-wide datasets facilitating the development of new statistical approaches to describe w...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0032891

Authors


Campino, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Djimde, AA More by this author
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Journal:
PloS one
Volume:
7
Issue:
2
Pages:
e32891-e32891
Publication date:
2012-01-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:07393ab7-f75f-41e0-82c0-984b78484891
Source identifiers:
315747
Local pid:
pubs:315747

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