Chiral phosphorothioate analogues of B-DNA. The crystal structure of Rp-d[Gp(S)CpGp(S)CpGp(S)C].

Journal article

The compound Rp-d[Gp(S)CpGp(S)CpGp(S)C], an analogue of the deoxyoligomer d(G-C)3, crystallizes in space group P2(1)2(1)2(1) with a = 34.90 A, b = 39.15 A and c = 20.64 A. The structure, which is not isomorphous with any previously determined deoxyoligonucleotide, was refined to an R factor of 14.5% at a resolution of 2.17 A, with 72 solvent molecules located. The two strands of the asymmetric unit form a right-handed double helix, which is a new example of a B-DNA conformation and brings to ...

Expand abstract

Authors: Cruse, W; Salisbury, SA; Brown, T; Cosstick, R; Eckstein, F

• Publication status: Published
• Journal: Journal of molecular biology
• Volume: 192
• Issue: 4
• Pages: 891-905
• Publication date: 1986-12-01
• DOI: 10.1016/0022-2836(86)90035-5
• EISSN: 1089-8638
• ISSN: 0022-2836
• Language: English
• Keywords: Oligodeoxyribonucleotides; Phosphates; Nucleic Acid Conformation; Crystallization; DNA; Thionucleotides; Ribose