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Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.

Abstract:
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e.
Publication status:
Published

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Publisher copy:
10.1039/b604835h

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemical Communications More from this journal
Issue:
25
Pages:
2664-2666
Publication date:
2006-07-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Language:
English
Pubs id:
pubs:110554
UUID:
uuid:072aa7db-8a9f-47c5-a8b9-5abe7f8e2bc3
Local pid:
pubs:110554
Source identifiers:
110554
Deposit date:
2012-12-19

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