Journal article

Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.

Abstract:: Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e.

Publication status:: Published

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APA Style

Davies, S., Garner, A., Goddard, E., Kruchinin, D., Roberts, P., Rodriguez-Solla, H., & Smith, A. (2006). Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines. Chemical Communications, 25, 2664–2666.

MLA Style

Davies, S, et al. “Lithium Amide Conjugate Addition for the Asymmetric Synthesis of 3-Aminopyrrolidines.” Chemical Communications, no. 25, 2006, pp. 2664–66.

Chicago Style

Davies, S, A Garner, E Goddard, et al. 2006. “Lithium Amide Conjugate Addition for the Asymmetric Synthesis of 3-Aminopyrrolidines.” Chemical Communications, no. 25: 2664–66.
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Publisher copy:: 10.1039/b604835h

Authors

+ Davies, S More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Garner, A More by this author

Role:: Author

+ Goddard, E More by this author

Role:: Author

+ Kruchinin, D More by this author

Role:: Author

+ Roberts, P More by this author

Role:: Author

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Journal:: Chemical Communications More from this journal
Issue:: 25
Pages:: 2664-2666
Publication date:: 2006-07-01
DOI:: 10.1039/b604835h
EISSN:: 1364-548X
ISSN:: 1359-7345

Language:: English
Pubs id:: pubs:110554
UUID:: uuid:072aa7db-8a9f-47c5-a8b9-5abe7f8e2bc3
Local pid:: pubs:110554
Source identifiers:: 110554
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_072aa7db8a9f47c5a8b95abe7f8e2bc3

Terms of use

Copyright date:: 2006

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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