Detection of human retrovirus 5 in patients with arthritis and systemic lupus erythematosus.

Journal article

OBJECTIVE: To examine whether human retrovirus 5 (HRV-5) infection is associated with autoimmune rheumatic disease. METHODS: DNA from patients with various disorders including inflammatory diseases and from normal subjects was tested by nested polymerase chain reaction (PCR) for HRV-5 proviral DNA. Positive results were confirmed by DNA sequencing. RESULTS: HRV-5 proviral DNA was detected in 53% of synovial samples from arthritic joints, in 12% of blood samples from patients with rheumatoid a...

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Authors: Griffiths, D; Cooke, S; Hervé, C; Rigby, S; Mallon, E

• Journal: Arthritis and rheumatism
• Volume: 42
• Issue: 3
• Pages: 448-454
• Publication date: 1999-03-01
• DOI: 10.1002/1529-0131(199904)42:3<448::aid-anr9>3.0.co;2-8
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Viscera; Molecular Sequence Data; Endogenous Retroviruses; Viral Load; Sequence Analysis, DNA; DNA Probes; RNA, Viral; Synovial Membrane; Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Base Sequence; Blotting, Southern; Humans; Polymerase Chain Reaction; Bronchoalveolar Lavage Fluid; DNA, Viral