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Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.

Abstract:

HLA-F is a human non-classical MHC molecule. Recombinant HLA-F heavy chain was refolded with 2-microglobulin to form a stable complex. This complex was used as an immunogen to produce a highly specific, high-affinity monoclonal antibody (FG1) that was used to study directly the cellular biology and tissue distribution of HLA-F. HLA-F has a restricted pattern of tissue expression in tonsil, spleen, and thymus. HLA-F could be immunoprecipitated from B cell lines and from HUT-78, a T cell line. ...

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Publication status:
Published

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Journal:
European journal of immunology More from this journal
Volume:
30
Issue:
12
Pages:
3552-3561
Publication date:
2000-12-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:18031
UUID:
uuid:0725d2bc-4ff6-4be9-86cd-b827c1934847
Local pid:
pubs:18031
Source identifiers:
18031
Deposit date:
2012-12-19

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