Modafinil for excessive daytime sleepiness in myotonic dystrophy type 1 - The patients' perspective

Journal article

Excessive daytime sleepiness (EDS), of very similar pattern to that seen in narcolepsy syndrome, is extremely common in myotonic dystrophy type 1 (DM1). In a significant minority it has a profound disabling effect on employment, social functioning and activities of daily living. Limited published studies have shown inconsistent results from use of the psychostimulant drug modafinil. A recent European Medicines Agency (EMA) review concluded that on current evidence regarding safety and efficac...

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Authors: Hilton-Jones, D; Bowler, M; Lochmueller, H; Longman, C; Petty, R

• Journal: Neuromuscular Disorders
• Volume: 22
• Issue: 7
• Pages: 597-603
• Publication date: 2012-07-01
• DOI: 10.1016/j.nmd.2012.02.005
• EISSN: 1873-2364
• ISSN: 0960-8966
• Language: English
• Keywords: Epworth sleepiness scale; Maintenance of wakefulness test; Multiple sleep latency test; Excessive daytime sleepiness; Myotonic dystrophy; Modafinil