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Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions

Abstract:

With no currently available disease-modifying drugs, Alzheimer’s disease is the most common type of dementia affecting over 47 million people worldwide. In light of the most recent discoveries placing the cellular prion protein (PrPC) as a key player in amyloid β oligomer (Aβo)-induced neurodegeneration, we investigated whether the neuroprotective potential of nature-inspired flavonoids against Aβ-promoted toxicity would translate into the ability to disrupt PrPC-Aβo interactions. Hence, we s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1515/pac-2019-0114

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Publisher:
De Gruyter
Journal:
Pure and Applied Chemistry More from this journal
Volume:
91
Issue:
7
Pages:
1107-1136
Publication date:
2019-04-29
Acceptance date:
2019-04-01
DOI:
EISSN:
1365-3075
ISSN:
0033-4545
Keywords:
Pubs id:
pubs:1037298
UUID:
uuid:072340da-e7da-4380-9d45-cab983195048
Local pid:
pubs:1037298
Source identifiers:
1037298
Deposit date:
2019-10-23

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