Journal article
Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions
- Abstract:
-
With no currently available disease-modifying drugs, Alzheimer’s disease is the most common type of dementia affecting over 47 million people worldwide. In light of the most recent discoveries placing the cellular prion protein (PrPC) as a key player in amyloid β oligomer (Aβo)-induced neurodegeneration, we investigated whether the neuroprotective potential of nature-inspired flavonoids against Aβ-promoted toxicity would translate into the ability to disrupt PrPC-Aβo interactions. Hence, we s...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- De Gruyter Publisher's website
- Journal:
- Pure and Applied Chemistry Journal website
- Volume:
- 91
- Issue:
- 7
- Pages:
- 1107-1136
- Publication date:
- 2019-04-29
- Acceptance date:
- 2019-04-01
- DOI:
- EISSN:
-
1365-3075
- ISSN:
-
0033-4545
Item Description
- Keywords:
- Pubs id:
-
pubs:1037298
- UUID:
-
uuid:072340da-e7da-4380-9d45-cab983195048
- Local pid:
- pubs:1037298
- Source identifiers:
-
1037298
- Deposit date:
- 2019-10-23
Terms of use
- Copyright holder:
- IUPAC & De Gruyter
- Copyright date:
- 2019
- Notes:
- ©2019 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/.
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