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Microevolutionary analysis of Clostridium difficile genomes to investigate transmission.

Abstract:

BACKGROUND: The control of Clostridium difficile infection is a major international healthcare priority, hindered by a limited understanding of transmission epidemiology for these bacteria. However, transmission studies of bacterial pathogens are rapidly being transformed by the advent of next generation sequencing. RESULTS: Here we sequence whole C. difficile genomes from 486 cases arising over four years in Oxfordshire. We show that we can estimate the times back to common ancestors of bact...

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Publication status:
Published

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Publisher copy:
10.1186/gb-2012-13-12-r118

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Journal:
Genome biology
Volume:
13
Issue:
12
Pages:
R118
Publication date:
2012-01-05
DOI:
EISSN:
1465-6914
ISSN:
1465-6906
URN:
uuid:07208198-adae-4926-b253-75b5c1ba24bc
Source identifiers:
369865
Local pid:
pubs:369865
Language:
English

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