Journal article
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
- Abstract:
-
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We ident...
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- Publisher copy:
- 10.1038/ng.2249
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Authors
Bibliographic Details
- Journal:
- Nature Genetics
- Volume:
- 44
- Issue:
- 5
- Pages:
- 491-501
- Publication date:
- 2012-05-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
329481
Item Description
- Language:
- English
- Pubs id:
-
pubs:329481
- UUID:
-
uuid:0719eb2e-a104-47cc-a872-21edeca4e578
- Local pid:
- pubs:329481
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
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