Journal article icon

Journal article

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

Abstract:

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We ident...

Expand abstract

Actions


Access Document


Publisher copy:
10.1038/ng.2249

Authors


Expand authors...
Journal:
Nature Genetics
Volume:
44
Issue:
5
Pages:
491-501
Publication date:
2012-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:0719eb2e-a104-47cc-a872-21edeca4e578
Source identifiers:
329481
Local pid:
pubs:329481
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP