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CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).

Abstract:

CYP17 encodes cytochrome p450c17alpha, which mediates activities essential for the production of sex steroids. Common germ line variation in the CYP17 gene has been related to inconsistent results in breast and prostate cancer, with most studies focusing on the nonsynonymous single nucleotide polymorphism (SNP) T27C (rs743572). We comprehensively characterized variation in CYP17 by direct sequencing of exons followed by dense genotyping across the 58 kb region around CYP17 in five racial/ethn...

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Publication status:
Published

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Authors


Setiawan, VW More by this author
Schumacher, FR More by this author
Haiman, CA More by this author
Albanes, D More by this author
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Journal:
Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume:
16
Issue:
11
Pages:
2237-2246
Publication date:
2007-11-05
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
URN:
uuid:0718f42b-dc14-4e4f-9f81-33206e109f47
Source identifiers:
57771
Local pid:
pubs:57771

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