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Enantioselective organocatalytic Michael additions to acrylic acid derivatives: generation of all-carbon quaternary stereocentres.

Abstract:
Acrylic esters, thioesters and N-acryloyl pyrrole have been identified as effective electrophiles in the enantioselective Michael addition reaction with beta-keto ester pro-nucleophiles catalysed by a cinchona alkaloid derived bifunctional organocatalyst; enantiomeric excesses of up to 98% and yields of up to 96% can be obtained for a range of Michael acceptors and pro-nucleophiles.
Publication status:
Published

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Publisher copy:
10.1039/b805233f

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
Chemical Communications More from this journal
Issue:
32
Pages:
3798-3800
Publication date:
2008-08-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345


Language:
English
Pubs id:
pubs:34342
UUID:
uuid:0715a1e7-6ede-4e18-8654-95ba16fddd3b
Local pid:
pubs:34342
Source identifiers:
34342
Deposit date:
2012-12-19
ARK identifier:

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