Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides.

Journal article

Ionotropic GABA receptors are abundant in both vertebrate and invertebrate nervous systems, where they mediate rapid, mostly inhibitory synaptic transmission. A GABA-gated chloride channel subunit from Drosophila melanogaster [Resistant to Dieldrin (RDL)] has been cloned, functionally expressed, and found to exhibit many aspects of the pharmacology of native, bicuculline-insensitive insect GABA receptors. RDL is the target of the commercially important insecticide fipronil. A point mutation i...

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Authors: Buckingham, S; Biggin, P; Sattelle, B; Brown, L; Sattelle, D

• Publication status: Published
• Journal: Molecular pharmacology
• Volume: 68
• Issue: 4
• Pages: 942-951
• Publication date: 2005-10-01
• DOI: 10.1124/mol.105.015313
• EISSN: 1521-0111
• ISSN: 0026-895X
• Language: English
• Keywords: Alternative Splicing; RNA Editing; Insecticide Resistance; Antiprotozoal Agents; RNA, Messenger; Amino Acid Sequence; Molecular Sequence Data; Receptors, GABA; Drosophila melanogaster; Insecticides; Animals; Sequence Homology, Amino Acid