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Tolerability and safety of artesunate-amodiaquine and artemether-lumefantrine fixed dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria: two open-label, randomized trials in Nimba County, Liberia.

Abstract:

Background: Safety surveillance of widely used artemisinin-based combination therapy (ACT) is essential, but tolerability data in the over five years age group are largely anecdotal.

Methods: Two open-label, randomized trials were conducted in Nimba County, Liberia: i) the main tolerability trial with 1,000 Plasmodium falciparum malaria patients aged over five years (Study-T), and, ii) an efficacy trial with a secondary objective of collecting tolerability data among 300 children ag...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/1475-2875-12-250

Authors


Schramm, B More by this author
Mazinda, CS More by this author
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Drugs for Neglected Diseases initiative More from this funder
Doctors Without Borders More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malar J Journal website
Volume:
12
Issue:
1
Pages:
Article: 250
Publication date:
2013
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:071456f7-cb0c-486e-9eb2-4b5a7102acc0
Source identifiers:
414689
Local pid:
pubs:414689

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