Journal article

The dynamics of signal triggering in a gp130-receptor complex.

Abstract:: gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.

Publication status:: Published

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APA Style

Matadeen, R., Hon, W., Heath, J., Jones, E., & Fuller, S. (2007). The dynamics of signal triggering in a gp130-receptor complex. Structure (London, England : 1993), 15(4), 441–448.

MLA Style

Matadeen, R, et al. “The Dynamics of Signal Triggering in a gp130-Receptor Complex.” Structure (London, England : 1993), vol. 15, no. 4, 2007, pp. 441–48.

Chicago Style

Matadeen, R, W Hon, J Heath, E Jones, and S Fuller. 2007. “The Dynamics of Signal Triggering in a gp130-Receptor Complex.” Structure (London, England : 1993) 15 (4): 441–48.
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Publisher copy:: 10.1016/j.str.2007.02.006

Authors

+ Matadeen, R More by this author

Role:: Author

+ Hon, W More by this author

Role:: Author

+ Heath, J More by this author

Role:: Author

+ Jones, E More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Structural Biology
Role:: Author

+ Fuller, S More by this author

Role:: Author

Journal:: Structure (London, England : 1993) More from this journal
Volume:: 15
Issue:: 4
Pages:: 441-448
Publication date:: 2007-04-01
DOI:: 10.1016/j.str.2007.02.006
EISSN:: 1878-4186
ISSN:: 0969-2126

Language:: English
Keywords:: Cytokine Receptor gp130

Protein Binding

Signal Transduction

Interleukin-11

Animals

Cryoelectron Microscopy

Mice

Receptors, Interleukin-11
Pubs id:: pubs:19737
UUID:: uuid:071102a9-9ea3-4c34-a4d7-29154580c9e3
Local pid:: pubs:19737
Source identifiers:: 19737
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_071102a99ea34c34a4d729154580c9e3

Terms of use

Copyright date:: 2007

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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