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Journal article

The dynamics of signal triggering in a gp130-receptor complex.

Abstract:

gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all th...

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Publication status:
Published

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Publisher copy:
10.1016/j.str.2007.02.006

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Structure (London, England : 1993) More from this journal
Volume:
15
Issue:
4
Pages:
441-448
Publication date:
2007-04-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Language:
English
Keywords:
Pubs id:
pubs:19737
UUID:
uuid:071102a9-9ea3-4c34-a4d7-29154580c9e3
Local pid:
pubs:19737
Source identifiers:
19737
Deposit date:
2012-12-19

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