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Journal article

Synthesis of 99mTc-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes.

Abstract:

PURPOSE: Few radiopharmaceuticals have been described for the study of lymphocyte trafficking despite its high clinical relevance. The main difficulty resides in the identification of a suitable highly specific probe to target these cells. Interleukin-12 (IL12) is a heterodimeric cytokine which plays a key role in the development of Th(1) lymphocytes. The aims of the present study were to label IL12 with (99m)Tc, to evaluate its ability to bind to activated T lymphocytes in vitro and to stud...

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Publication status:
Published

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Publisher copy:
10.1007/s00259-005-0001-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
European journal of nuclear medicine and molecular imaging
Volume:
33
Issue:
4
Pages:
474-482
Publication date:
2006-04-01
DOI:
EISSN:
1619-7089
ISSN:
1619-7070
Source identifiers:
255360
Language:
English
Keywords:
Pubs id:
pubs:255360
UUID:
uuid:0710801e-e400-45fb-9fd8-f783b1ad84e2
Local pid:
pubs:255360
Deposit date:
2013-11-16

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