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Journal article

Inactivation of the KcsA potassium channel explored with heterotetramers.

Abstract:

The tetrameric prokaryotic potassium channel KcsA is activated by protons acting on the intracellular aspect of the protein and inactivated through conformational changes in the selectivity filter. Inactivation is modulated by a network of interactions within each protomer between the pore helix and residues at the external entrance of the channel. Inactivation is suppressed by the E71A mutation, which perturbs the stability of this network. Here, cell-free protein synthesis followed by prote...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.200910305

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Journal:
Journal of general physiology
Volume:
135
Issue:
1
Pages:
29-42
Publication date:
2010-01-01
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
Source identifiers:
52270
Language:
English
Keywords:
Pubs id:
pubs:52270
UUID:
uuid:070967ba-3434-4551-8753-0d8ce637ed7c
Local pid:
pubs:52270
Deposit date:
2013-11-17

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