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Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways.

Abstract:

Saccharomyces cerevisiae YFR021w, YGR223c and YPL100w are paralogous ORFs of unknown function. Phenotypic analysis of overexpression, single-, double- and triple-ORF deletion strains under various growth conditions indicated mitochondria-related functions for all three ORFs. Two-hybrid screens of a yeast genomic library identified potentially interacting proteins for the three ORFs. Among these, the transcriptional activator Rtg3p interacted with both Yfr021wp and Ypl100wp and both ORF single...

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Publication status:
Published

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Publisher copy:
10.1002/yea.764

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
Yeast (Chichester, England)
Volume:
18
Issue:
12
Pages:
1155-1171
Publication date:
2001-09-05
DOI:
EISSN:
1097-0061
ISSN:
0749-503X
URN:
uuid:06fffeac-8691-470f-addf-cc295b10e218
Source identifiers:
196787
Local pid:
pubs:196787

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