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Analysis of frequency and phenotype of antigen-specific T cells.

Abstract:

Over the last decade, our understanding of the cellular immune system has been greatly advanced through the development of methods to identify antigen-specific T cells directly ex vivo. The major reagents and techniques used for this purpose are (i) tetramerised MHC:peptide complexes (tetramers) which bind to specific T-cell receptors (TCR) and (ii) assays that detect T cells which synthesise cytokines in response to cognate stimulation (intracellular cytokine staining (ICS)). Here, we provid...

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Publisher copy:
10.1007/978-1-60327-527-9_1

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
514
Pages:
1-14
Publication date:
2009
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:06fc64b8-f815-43ad-9e1f-b04a44c8e1e2
Source identifiers:
34499
Local pid:
pubs:34499

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