- Abstract:
-
Understanding the mechanisms of evolution requires identification of the molecular basis of the multiple (pleiotropic) effects of specific adaptive mutations. We have characterized the pleiotropic effects on protein levels of an adaptive single-base pair substitution in the coding sequence of a signaling pathway gene in the bacterium Pseudomonas fluorescens SBW25. We find 52 proteomic changes, corresponding to 46 identified proteins. None of these proteins is required for the adaptive phenoty...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1038/ng1867
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 38
- Issue:
- 9
- Pages:
- 1015-1022
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:06e83350-2eca-4530-bb9f-b64e2f55a99f
- Source identifiers:
-
99813
- Local pid:
- pubs:99813
- Copyright holder:
- Nature Publishing Group
- Notes:
- © 2006 Nature Publishing Group. The final version is available online from Nature Publishing Group at: [10.1038/ng1867]
Journal article
Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network.
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