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Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network.

Abstract:

Understanding the mechanisms of evolution requires identification of the molecular basis of the multiple (pleiotropic) effects of specific adaptive mutations. We have characterized the pleiotropic effects on protein levels of an adaptive single-base pair substitution in the coding sequence of a signaling pathway gene in the bacterium Pseudomonas fluorescens SBW25. We find 52 proteomic changes, corresponding to 46 identified proteins. None of these proteins is required for the adaptive phenoty...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng1867

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
38
Issue:
9
Pages:
1015-1022
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:06e83350-2eca-4530-bb9f-b64e2f55a99f
Source identifiers:
99813
Local pid:
pubs:99813

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