Journal article
Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network.
- Abstract:
-
Understanding the mechanisms of evolution requires identification of the molecular basis of the multiple (pleiotropic) effects of specific adaptive mutations. We have characterized the pleiotropic effects on protein levels of an adaptive single-base pair substitution in the coding sequence of a signaling pathway gene in the bacterium Pseudomonas fluorescens SBW25. We find 52 proteomic changes, corresponding to 46 identified proteins. None of these proteins is required for the adaptive phenoty...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/ng1867
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 38
- Issue:
- 9
- Pages:
- 1015-1022
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
99813
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:99813
- UUID:
-
uuid:06e83350-2eca-4530-bb9f-b64e2f55a99f
- Local pid:
- pubs:99813
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Nature Publishing Group
- Notes:
- © 2006 Nature Publishing Group. The final version is available online from Nature Publishing Group at: [10.1038/ng1867]
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