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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Abstract:: The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents. In contrast, information regarding the roles of this hormone in humans is limited. Three morbidly obese children, who were congenitally deficient in leptin, were treated with daily subcutaneous injections of recombinant human leptin for up to 4 years wit...
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Publication status:: Published

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APA Style

Farooqi, I., Matarese, G., Lord, G., Keogh, J., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., Lechler, R., DePaoli, A., & O'Rahilly, S. (2002). Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. JOURNAL OF CLINICAL INVESTIGATION, 110(8), 1093–1103.

MLA Style

Farooqi, I., et al. “Beneficial Effects of Leptin on Obesity, T Cell Hyporesponsiveness, and Neuroendocrine/Metabolic Dysfunction of Human Congenital Leptin Deficiency.” JOURNAL OF CLINICAL INVESTIGATION, vol. 110, no. 8, 2002, pp. 1093–103.

Chicago Style

Farooqi, I, G Matarese, G Lord, J Keogh, E Lawrence, C Agwu, V Sanna, et al. 2002. “Beneficial Effects of Leptin on Obesity, T Cell Hyporesponsiveness, and Neuroendocrine/Metabolic Dysfunction of Human Congenital Leptin Deficiency.” JOURNAL OF CLINICAL INVESTIGATION 110 (8): 1093–1103.
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Publisher copy:: 10.1172/JCI200215693

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+ Matarese, G More by this author

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+ Lord, G More by this author

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Bibliographic Details

Journal:: JOURNAL OF CLINICAL INVESTIGATION
Volume:: 110
Issue:: 8
Pages:: 1093-1103
Publication date:: 2002-10-01
DOI:: 10.1172/JCI200215693
ISSN:: 0021-9738

Item Description

Language:: English
Pubs id:: pubs:430000
UUID:: uuid:06e0e0e8-bf73-4b36-a1ec-53912d22a350
Local pid:: pubs:430000
Source identifiers:: 430000
Deposit date:: 2013-11-16

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Copyright date:: 2002

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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