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Simultaneous quantification of Plasmodium antigens and host factor CRP in asymptomatic individuals with confirmed malaria using a novel multiplex immunoassay

Abstract:

Malaria rapid diagnostic tests (RDTs) primarily detect Plasmodium falciparum antigen histidine-rich protein 2 (HRP2) and the malaria-conserved antigen lactate dehydrogenase (LDH) for P. vivax and other malaria species. The performance of RDTs and their utility is dependent on circulating antigen concentration distributions in infected individuals in a population in which malaria is endemic and on the limit of detection of the RDT for the antigens. A multiplexed immunoassay for the quantificat...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/jcm.00948-18

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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Clinical Microbiology Journal website
Volume:
57
Issue:
1
Pages:
e00948-18
Publication date:
2019-01-02
Acceptance date:
2018-11-07
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Pubs id:
pubs:941138
URN:
uri:06df2c5d-c0e0-44d6-9f2e-70f4e27575ac
UUID:
uuid:06df2c5d-c0e0-44d6-9f2e-70f4e27575ac
Local pid:
pubs:941138
Language:
English
Keywords:

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