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Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines.

Abstract:

Ras activation promotes the survival of tumor cells after DNA damage. To reverse this survival advantage, Ras signaling has been targeted for inhibition. Other contributors to Ras-mediated DNA damage survival have been identified using pharmacologic inhibition of signaling, but this approach is limited by the specificity of the inhibitors used and their toxicity. To better define components of Ras signaling that could be inhibited in a clinical setting, RNA interference was used to selectivel...

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Publication status:
Published

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Authors


Fernandes, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Cancer research
Volume:
65
Issue:
17
Pages:
7902-7910
Publication date:
2005-09-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:06dc4982-f47b-4a9b-8f1a-5fc96a518f31
Source identifiers:
118209
Local pid:
pubs:118209

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