- Abstract:
-
Calcitonin is a circulating polypeptide that inhibits bone resorption by inducing both quiescence (Q effect) and retraction (R effect) in osteoclasts. Two structurally related members of the calcitonin gene peptide family, calcitonin gene-related peptide (CGRP) and amylin, inhibit osteoclastic bone resorption selectively via the Q effect. In the present study, we have made measurements of cell spread area in response to the application of amylin, CGRP and a peptide fragment of CGRP, CGRP-(Val...
Expand abstract - Publisher copy:
- 10.1677/joe.0.1360007
-
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- Journal:
- The Journal of endocrinology
- Volume:
- 136
- Issue:
- 1
- Pages:
- 7-15
- Publication date:
- 1993-01-05
- DOI:
- EISSN:
-
1479-6805
- ISSN:
-
0022-0795
- URN:
-
uuid:06d5bd95-3285-43c0-8e2d-47ced2e9b0d1
- Source identifiers:
-
475698
- Local pid:
- pubs:475698
- Copyright date:
- 1993
Journal article
Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site mediating intracellular Ca2+ mobilization and cell retraction.
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