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Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site mediating intracellular Ca2+ mobilization and cell retraction.

Abstract:

Calcitonin is a circulating polypeptide that inhibits bone resorption by inducing both quiescence (Q effect) and retraction (R effect) in osteoclasts. Two structurally related members of the calcitonin gene peptide family, calcitonin gene-related peptide (CGRP) and amylin, inhibit osteoclastic bone resorption selectively via the Q effect. In the present study, we have made measurements of cell spread area in response to the application of amylin, CGRP and a peptide fragment of CGRP, CGRP-(Val...

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Publisher copy:
10.1677/joe.0.1360007

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Journal:
The Journal of endocrinology
Volume:
136
Issue:
1
Pages:
7-15
Publication date:
1993-01-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:06d5bd95-3285-43c0-8e2d-47ced2e9b0d1
Source identifiers:
475698
Local pid:
pubs:475698

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