Neonatal diabetes.

Journal article

ATP-sensitive potassium (KATP) channels are inhibited by intracellular ATP and activated by MgADP. As a consequence, they couple the metabolic state of the cell to its electrical activity. In pancreatic Beta-cells KATP channels regulate glucose-dependent insulin secretion and are the target for sulphonylurea drugs clinically employed in the treatment of type 2 diabetes. This review discusses recent advances in our understanding of the role of KATP channels in permanent neonatal diabetes mellitus.

Authors: Tammaro, P

• Journal: Endocrine development
• Volume: 11
• Pages: 70-82
• Publication date: 2007-01-01
• DOI: 10.1159/000111059
• EISSN: 1662-2979
• ISSN: 1421-7082
• Language: English
• Keywords: Insulin-Secreting Cells; Models, Molecular; Mutation; Infant, Newborn; KATP Channels; Humans; Diabetes Mellitus; Models, Biological