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Journal article

TLR15 is unique to avian and reptilian lineages and recognizes a yeast-derived agonist.

Abstract:

The TLRs represent a family of pattern recognition receptors critical in the induction of vertebrate immune responses. Between 10 and 13 different TLR genes can be identified in each vertebrate species, with many represented as orthologous genes in different species. The agonist specificity of orthologous TLR is also highly conserved. In contrast, TLR15 can only be identified in avian and reptilian genomes, suggesting that this receptor arose ~320 million years ago after divergence of the bir...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1101790

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Journal:
Journal of Immunology
Volume:
189
Issue:
10
Pages:
4930-4938
Publication date:
2012-11-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
356267
Language:
English
Keywords:
Pubs id:
pubs:356267
UUID:
uuid:06c1fc1a-b21c-4888-9ef3-9c2c8c62f8cd
Local pid:
pubs:356267
Deposit date:
2013-11-16

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