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Journal article

TLR15 is unique to avian and reptilian lineages and recognizes a yeast-derived agonist.

Abstract:

The TLRs represent a family of pattern recognition receptors critical in the induction of vertebrate immune responses. Between 10 and 13 different TLR genes can be identified in each vertebrate species, with many represented as orthologous genes in different species. The agonist specificity of orthologous TLR is also highly conserved. In contrast, TLR15 can only be identified in avian and reptilian genomes, suggesting that this receptor arose ~320 million years ago after divergence of the bir...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1101790

Authors


Peroval, MY More by this author
Hammond, JA More by this author
Prickett, MD More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
189
Issue:
10
Pages:
4930-4938
Publication date:
2012-11-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:06c1fc1a-b21c-4888-9ef3-9c2c8c62f8cd
Source identifiers:
356267
Local pid:
pubs:356267

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