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Journal article

Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci.

Abstract:

CONTEXT: There is limited evidence on how the risk of breast cancer and its subtypes depend on low-penetrance susceptibility loci, individually or in combination. OBJECTIVE: To analyze breast cancer risk, overall and by tumor subtype, in relation to 14 individual single-nucleotide polymorphisms (SNPs) previously linked to the disease, and in relation to a polygenic risk score. DESIGN, SETTING, AND PARTICIPANTS: Study of 10,306 women with breast cancer (mean age at diagnosis, 58 years) and 10,...

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Publication status:
Published

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Publisher copy:
10.1001/jama.2010.1042

Authors


Reeves, GK More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit, BHF Centre of Research Excellence
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Journal:
JAMA
Volume:
304
Issue:
4
Pages:
426-434
Publication date:
2010-07-05
DOI:
EISSN:
1538-3598
ISSN:
0098-7484
URN:
uuid:06b73263-4f1f-4296-bab1-ffb9d5b2e91d
Source identifiers:
65922
Local pid:
pubs:65922

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