- Abstract:
-
Delta-like 4 (DLL4), a membrane-bound ligand belonging to the Notch signaling family, plays a fundamental role in vascular development and angiogenesis. We identified a conserved microRNA family, miR-30, which targets DLL4. Overexpression of miR-30b in endothelial cells led to increased vessel number and length in an in vitro model of sprouting angiogenesis. Microinjection of miR-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmen...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2012-04-423004
-
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- Journal:
- Blood
- Volume:
- 120
- Issue:
- 25
- Pages:
- 5063-5072
- Publication date:
- 2012-12-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:06b714c2-c110-4902-a826-1d1f13e2267c
- Source identifiers:
-
356221
- Local pid:
- pubs:356221
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.
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