Journal article icon

Journal article

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.

Abstract:

Delta-like 4 (DLL4), a membrane-bound ligand belonging to the Notch signaling family, plays a fundamental role in vascular development and angiogenesis. We identified a conserved microRNA family, miR-30, which targets DLL4. Overexpression of miR-30b in endothelial cells led to increased vessel number and length in an in vitro model of sprouting angiogenesis. Microinjection of miR-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmen...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, BHF Centre of Research Excellence
Role:
Author
Expand authors...
Journal:
Blood
Volume:
120
Issue:
25
Pages:
5063-5072
Publication date:
2012-12-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:06b714c2-c110-4902-a826-1d1f13e2267c
Source identifiers:
356221
Local pid:
pubs:356221

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP