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Journal article

lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast.

Abstract:

Numerous noncoding transcripts of unknown function have recently been identified. In this study, we report a novel mechanism that relies on transcription of noncoding RNA prt (pho1-repressing transcript) regulating expression of the pho1 gene. A product of this gene, Pho1, is a major secreted phosphatase needed for uptake of extracellular phosphate in fission yeast. prt is produced from the promoter located upstream of the pho1 gene in response to phosphate, and its transcription leads to dep...

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Publication status:
Published

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Publisher copy:
10.1101/gad.230177.113

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Genes and development More from this journal
Volume:
28
Issue:
3
Pages:
231-244
Publication date:
2014-02-01
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Language:
English
Keywords:
Pubs id:
pubs:447804
UUID:
uuid:06b4ae13-b9a9-4aaf-8947-0700ff89453e
Local pid:
pubs:447804
Source identifiers:
447804
Deposit date:
2014-08-16

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