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Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

Abstract:

The hypoxic response in animals is mediated via the transcription factor hypoxia-inducible factor (HIF). An oxygen-sensing component of the HIF system is provided by Fe(II) and 2-oxoglutarate-dependent oxygenases that catalyse the posttranslational hydroxylation of the HIF-α subunit. It is proposed that the activity of the HIF hydroxylases can be regulated by their reaction with nitric oxide. We describe biochemical and biophysical studies on the reaction of prolyl hydroxylase domain-containi...

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Publisher copy:
10.1016/j.jmb.2011.04.075

Authors


Journal:
Journal of Molecular Biology More from this journal
Volume:
410
Issue:
2
Pages:
268-279
Publication date:
2011-07-08
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Language:
English
Keywords:
Pubs id:
pubs:164035
UUID:
uuid:06b40120-0001-42ef-a957-98a672c03249
Local pid:
pubs:164035
Source identifiers:
164035
Deposit date:
2012-12-19

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