Reticulin accumulation in essential thrombocythemia: prognostic significance and relationship to therapy.

Journal article

PURPOSE: Essential thrombocythemia (ET) manifests substantial interpatient heterogeneity in rates of thrombosis, hemorrhage, and disease transformation. Bone marrow histology reflects underlying disease activity in ET but many morphological features show poor reproducibility. PATIENTS AND METHODS: We evaluated the clinical significance of bone marrow reticulin, a measure previously shown to have relatively high interobserver reliability, in a large, prospectively-studied cohort of ET patients...

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Authors: Campbell, P; Bareford, D; Erber, W; Wilkins, B; Wright, P

• Publication status: Published
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• Volume: 27
• Issue: 18
• Pages: 2991-2999
• Publication date: 2009-06-01
• DOI: 10.1200/jco.2008.20.3174
• EISSN: 1527-7755
• ISSN: 0732-183X
• Language: English
• Keywords: Biological Markers; Prospective Studies; Hemorrhage; Prognosis; Bone Marrow; Leukocyte Count; Reticulin; Hydroxyurea; Hemoglobins; Thrombocythemia, Essential; Primary Myelofibrosis; Platelet Aggregation Inhibitors; Quinazolines; Thrombosis; Humans; Platelet Count