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The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis

Abstract:

Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6 is essential for neural stem cell proliferation, multipotency, and neurogenesis in many regions of the central nervous system, including the cerebral cortex. We used Pax6 as an entry point to define the cellular networks controlling neural stem cell self-renewal and neurogenesis in stem ce...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1000511

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Genetics More from this journal
Volume:
5
Issue:
6
Pages:
ARTN e1000511
Publication date:
2009-06-12
Acceptance date:
2009-05-12
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
UUID:
uuid:06b1ab75-a08e-41b0-a660-3293ca42e838
Local pid:
pubs:482775
Source identifiers:
482775
Deposit date:
2014-09-17

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