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Journal article

Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.

Abstract:

Little is known about the clonal structure or stem cell architecture of the human small intestinal crypt/villus unit, or how mutations spread and become fixed. Using mitochondrial DNA (mtDNA) mutations as a marker of clonal expansion of stem cell progeny, we aimed to provide answers to these questions. Enzyme histochemistry (for cytochrome c oxidase and succinate dehydrogenase) was performed on frozen sections of normal human duodenum. Laser-capture microdissected cells were taken from crypts...

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Publication status:
Published

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Publisher copy:
10.1002/path.2502

Authors


Gutierrez-Gonzalez, L More by this author
Deheragoda, M More by this author
Leedham, SJ More by this author
Shankar, A More by this author
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Journal:
The Journal of pathology
Volume:
217
Issue:
4
Pages:
489-496
Publication date:
2009-03-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:06aeb0bb-9408-4167-a4a7-52b57dba5e21
Source identifiers:
112465
Local pid:
pubs:112465

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