Journal article icon

Journal article

Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.

Abstract:

Little is known about the clonal structure or stem cell architecture of the human small intestinal crypt/villus unit, or how mutations spread and become fixed. Using mitochondrial DNA (mtDNA) mutations as a marker of clonal expansion of stem cell progeny, we aimed to provide answers to these questions. Enzyme histochemistry (for cytochrome c oxidase and succinate dehydrogenase) was performed on frozen sections of normal human duodenum. Laser-capture microdissected cells were taken from crypts...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/path.2502

Authors


Journal:
Journal of pathology More from this journal
Volume:
217
Issue:
4
Pages:
489-496
Publication date:
2009-03-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Pubs id:
pubs:112465
UUID:
uuid:06aeb0bb-9408-4167-a4a7-52b57dba5e21
Local pid:
pubs:112465
Source identifiers:
112465
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP