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Journal article

Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224.

Abstract:

Mirtrons are a recently described category of microRNA (miRNA) relying on splicing rather than processing by the microprocessor complex to generate pre-miRNA precursors of the RNA interference (RNAi) pathway. Their discovery and subsequent verification provides important information about a distinct class of miRNA and inherent advantages that could be exploited to silence genes of interest. These include micro-processor-independent biogenesis, pol-II-dependent transcription, accurate species ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gks712

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Name:
Parkinson’s UK
Funding agency for:
Wood, M
More from this funder
Name:
National Research Foundation, South Africa
Funding agency for:
Weinberg, MS
More from this funder
Name:
Oppenheimer Trust
Funding agency for:
Weinberg, MS
More from this funder
Name:
Agency for Science, Technology and Research
Funding agency for:
Seow, Y
More from this funder
Name:
Medical Research Council
Funding agency for:
Sibley, C
Wood, M
Publisher:
Oxford University Press
Journal:
Nucleic acids research More from this journal
Volume:
40
Issue:
19
Pages:
9863-9875
Publication date:
2012-10-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:344196
UUID:
uuid:06aaa161-9e7b-43df-8b95-26a000d33636
Local pid:
pubs:344196
Source identifiers:
344196
Deposit date:
2013-11-16

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