Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels.

Journal article

Morvan's 'fibrillary chorea' or Morvan's syndrome is characterized by neuromyotonia (NMT), pain, hyperhydrosis, weight loss, severe insomnia and hallucinations. We describe a man aged 76 years with NMT, dysautonomia, cardiac arrhythmia, lack of slow-wave sleep and abnormal rapid eye movement sleep. He had raised serum antibodies to voltage-gated K(+) channels (VGKC), oligoclonal bands in his CSF, markedly increased serum norepinephrine, increased serum cortisol and reduced levels and absent c...

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Authors: Liguori, R; Vincent, A; Clover, L; Avoni, P; Plazzi, G

• Publication status: Published
• Journal: Brain : a journal of neurology
• Volume: 124
• Issue: Pt 12
• Pages: 2417-2426
• Publication date: 2001-12-01
• DOI: 10.1093/brain/124.12.2417
• EISSN: 1460-2156
• ISSN: 0006-8950
• Language: English
• Keywords: Peripheral Nervous System; Sleep Disorders; Electroencephalography; Potassium Channels, Voltage-Gated; Male; Autoantibodies; Isaacs Syndrome; Myokymia; Electromyography; Brain; Humans; Aged; Prolactin; Norepinephrine; Arrhythmias, Cardiac; Circadian Rhythm; Melatonin; Fatal Outcome