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Morvan's syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels.

Abstract:

Morvan's 'fibrillary chorea' or Morvan's syndrome is characterized by neuromyotonia (NMT), pain, hyperhydrosis, weight loss, severe insomnia and hallucinations. We describe a man aged 76 years with NMT, dysautonomia, cardiac arrhythmia, lack of slow-wave sleep and abnormal rapid eye movement sleep. He had raised serum antibodies to voltage-gated K(+) channels (VGKC), oligoclonal bands in his CSF, markedly increased serum norepinephrine, increased serum cortisol and reduced levels and absent c...

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Publication status:
Published

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Publisher copy:
10.1093/brain/124.12.2417

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Brain : a journal of neurology More from this journal
Volume:
124
Issue:
Pt 12
Pages:
2417-2426
Publication date:
2001-12-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:242358
UUID:
uuid:06aa3969-6510-48c3-b11a-f38dc17e412f
Local pid:
pubs:242358
Source identifiers:
242358
Deposit date:
2012-12-19

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