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Cellular and molecular mechanisms of bone damage and repair in inflammatory arthritis

Abstract:

Bone remodelling relies on tightly controlled cycles of bone resorption and formation, mediated by osteoclasts and osteoblasts, respectively. The past two decades have seen a huge increase in our understanding of immune modulation and disruption of bone homeostasis in rheumatic diseases; identification of the molecular pathways responsible for accelerated bone loss in such conditions has given rise to potential novel therapeutic targets. Most recently, the role of microRNAs in inflammatory an...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
Elsevier
Journal:
Drug Discovery Today More from this journal
Volume:
19
Issue:
8
Pages:
1178-1185
Publication date:
2014-01-01
DOI:
EISSN:
1878-5832
ISSN:
1359-6446
Language:
English
Pubs id:
pubs:483293
UUID:
uuid:06935c56-e6f3-4396-afbc-651f609caaaf
Local pid:
pubs:483293
Source identifiers:
483293
Deposit date:
2014-09-11

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