- Abstract:
-
Structured noncoding RNAs underlie fundamental cellular processes, but determining their three-dimensional structures remains challenging. We demonstrate that integrating 1H NMR chemical shift data with Rosetta de novo modeling can be used to consistently determine high-resolution RNA structures. On a benchmark set of 23 noncanonical RNA motifs, including 11 'blind' targets, chemical-shift Rosetta for RNA (CS-Rosetta-RNA) recovered experimental structures with high accuracy (0.6-2.0 Å all-hea...
Expand abstract - Publisher copy:
- 10.1038/nmeth.2876
-
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- Publisher:
- Nature Publishing Group
- Journal:
- Nature Methods
- Volume:
- 11
- Issue:
- 4
- Pages:
- 413-416
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
-
1548-7105
- ISSN:
-
1548-7091
- URN:
-
uuid:06919519-9954-4040-8d3d-50419bc6aeb6
- Source identifiers:
-
462728
- Local pid:
- pubs:462728
- Language:
- English
- Copyright date:
- 2014
Journal article
Structure determination of noncanonical RNA motifs guided by 1 H NMR chemical shifts
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