Journal article
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
- Abstract:
-
Objective
Patients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with IBD, but neither the significance nor the functional mechanism of this association is clear. We studied bacterial handling and antibacterial autophagy in patients with NPC1.
Design
We characterised intestinal inflammation in 14 patients with NPC1 who developed IBD. We investigated bacterial handling and cyt...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1136/gutjnl-2015-310382
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Authors
Funding
+ Deutsche Forschungsgemeinschaft
More from this funder
Funding agency for:
Schwerd, T
Grant:
SCHW1730/1-1
+ Sapere Aude: Danish Council for Independent Research
More from this funder
Funding agency for:
Gyrd-Hansen, M
Grant:
102894/Z/13/Z
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Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Gut Journal website
- Publication date:
- 2016-03-01
- Acceptance date:
- 2016-01-14
- DOI:
- EISSN:
-
1468-3288
- ISSN:
-
0017-5749
- Source identifiers:
-
609214
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:609214
- UUID:
-
uuid:068f032d-262e-46b8-bf81-3e023839b419
- Local pid:
- pubs:609214
- Deposit date:
- 2016-03-26
Terms of use
- Copyright holder:
- Uhlig et al
- Copyright date:
- 2016
- Notes:
- This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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