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The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.

Abstract:

OBJECTIVE: To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA). METHODS: The Ile585Val TRPV1 variant encoded by rs8065080 was genotyped in 3270 cases of symptomatic knee OA, 1098 cases of asymptomatic knee OA and 3852 controls from seven cohorts from the UK, the USA and Australia. The genetic association between the low-pain genotype Ile-Ile and risk of...

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Publication status:
Published

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Publisher copy:
10.1136/ard.2010.148122

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Journal:
Annals of the rheumatic diseases More from this journal
Volume:
70
Issue:
9
Pages:
1556-1561
Publication date:
2011-09-01
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
Language:
English
Keywords:
Pubs id:
pubs:172549
UUID:
uuid:068487e6-803a-45aa-bdfe-e7b29f0ae3e6
Local pid:
pubs:172549
Source identifiers:
172549
Deposit date:
2012-12-19

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