The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.

Journal article

OBJECTIVE: To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA). METHODS: The Ile585Val TRPV1 variant encoded by rs8065080 was genotyped in 3270 cases of symptomatic knee OA, 1098 cases of asymptomatic knee OA and 3852 controls from seven cohorts from the UK, the USA and Australia. The genetic association between the low-pain genotype Ile-Ile and risk of...

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Authors: Valdes, A; De Wilde, G; Doherty, SA; Lories, R; Vaughn, F

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 70
• Issue: 9
• Pages: 1556-1561
• Publication date: 2011-09-01
• DOI: 10.1136/ard.2010.148122
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Case-Control Studies; Male; Aged; Female; Gene Frequency; Osteoarthritis, Knee; Pain; Middle Aged; Genetic Predisposition to Disease; Genotype; Cartilage, Articular; TRPV Cation Channels; Genetic Variation; Humans; Tissue Culture Techniques