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The conformation of an inhibitor bound to the gastric proton pump.

Abstract:

Substituted imidazo[1,2-a]pyridines are pharmaceutically important small molecule inhibitors of the gastric H+/K+-ATPase, the membrane-bound therapeutic target for peptic ulcer disease. A non-perturbing analytical technique, rotational resonance NMR spectroscopy, was used to measure a precise (to +/-0.2 A) distance between atomic sites in a substituted imidazo[1,2-a]pyridine, TMPIP, bound to H+/K+-ATPase at its high-affinity site in the intact, native membrane. The structural analysis of the ...

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Publication status:
Published

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Authors


Middleton, DA More by this author
Levitt, MH More by this author
Spiers, ID More by this author
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Journal:
FEBS letters
Volume:
410
Issue:
2-3
Pages:
269-274
Publication date:
1997-06-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:0681c586-c3d1-458f-b9c1-1af4f4f37ca4
Source identifiers:
410496
Local pid:
pubs:410496

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